Saturday, July 19, 2008

Oral Medication for MS, Trials Enrolling!

Do you want an oral MS drug? No more needles? Then please consider enrolling in one of the TWO Laquinimod Phase III studies. I don’t qualify so please volunteer for me!

Details for the BRAVO study, comparing Laquinimod to the drug to Avonex, is listed at ClinicalTtrials.gov site.

Details for the ALLEGRO Study, comparing Laquinimod to a placebo, can be found at the ALLEGRO Study web site.

The oral medication will be taken in both ALLEGRO and BRAVO phase III studies.

Here is some background information from the MS Foundation website:

July 17, 2008
A phase III clinical study comparing the experimental oral MS medication laquinimod to the injectable disease-modifying drug Avonex is now enrolling.


The 24-month, double-blind BRAVO trial will involve 1,200 people with relapsing-remitting MS (RRMS) worldwide. It follows a phase II trial of laquinimod which found that the oral medication significantly reduced disease activity as measured by MRI.

Participants in the BRAVO trial will be divided into three groups, those who take 0.6 mg of oral laquinimod daily, those who take a daily oral placebo, and those who receive weekly injections of Avonex.

Those who have previously used the disease-modifying drugs Avonex, Betaseron, Rebif, Tysabri, as well as laquinimod or cladribine, will be excluded from the BRAVO study.

Another phase III clinical study of laquinimod, known as the ALLEGRO trial, also is ongoing and examines the efficiency, tolerability and safety of the oral medication verses a placebo.

Laquinimod is being developed by Teva Pharmaceuticals, which also developed and distributes the injectable disease-modifying drug Copaxone.

More information on ALLEGRO can be found at www.tevaclinicaltrials.com. For more information about the BRAVO trial, call 1-800-840-5601 or visit www.clinicaltrials.gov.

4 comments:

  1. You keep up on the important stuff so I don't have to. Thanks again for the info.

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  2. hi,
    thanks for this valuable information..
    Clinical research is an upcoming field with lots of potential. Realizing this, many new institutes have come up with various courses in clinical research. India has number of quality institutes in clinical research.
    I would like to highlight that ICRI is also one of the premier institutes in drug research in the country.

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  3. It's always nice to see more info, and I am so hoping to stop these injections. I have done it all now with the exception of tysabri, and I think I'm going sit that one out. The chemotherapy was no fun, and it did nothing for me. I've been doing this dance since my diagnosis in 1988 and I'm just like Hughie Lewis, I want a new drug! Take care,

    awb

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  4. Thanks for that information, Pooja! This is a global disease and I'm glad to have feedback from outside the US.

    And thanks, AWB, for the THEME SONG!!! What a great idea.

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